ABSTRACT
The rearrangement reaction of benzyl phenyl ethers (BPE) plays an important role in the organic chemistry and drug synthesis .This paper briefly reviewed the rearrangement reaction and its possible mechanism in various catalytic sys-tems ,such as trifluoroacetic acid ,phosphotungstic acid ,cyclodextrin ,molten tin and aluminium bromide .
ABSTRACT
Objective The phosphoinositide 3-kinase (PI3K) constituted an important family of lipid kinase enzymes that control a range of cellular proliferation , differentiation and apoptosis through their regulation of a network of signal transduction path -ways, which had emerged as important therapeutic targets in the context of cancer and inflammation .Considerable progress had been made in the discovery and development of small molecular inhibitors targeting PI 3K.Progress in dual PI3K-mTOR inhibitors, a number of which had entered early phase clinical trials over recent years was summarized .